NANOTECHNOLOGY BASED APPROACHES FOR ENHANCING BIOAVAILABILITY OF POORLY SOLUBLE DRUGS

Abstract

Nanotechnology has emerged as a transformative field in pharmaceutical research, offering innovative solutions to tackle the long-standing challenge of poor solubility of various drugs. In this chapter, we explore the latest advancements and applications of nanotechnology-based solubility enhancement techniques. The poor aqueous solubility of drugs often leads to compromised bioavailability and therapeutic efficacy, limiting their clinical success. Nanotechnology-based approaches, such as nanosuspensions, solid lipid nanoparticles, nanoemulsions, and cyclodextrin complexes, have shown great promise in enhancing drug solubility and dissolution rates. By manipulating materials at the nanoscale, these techniques provide unique opportunities to encapsulate drug compounds, enhancing their stability and facilitating targeted delivery to specific biological sites. Moreover, the use of nanoscale carriers enables controlled and sustained drug release, leading to improved therapeutic outcomes and reduced side effects. This review highlights the versatility of nanotechnology in enhancing the solubility of hydrophobic and hydrophilic drugs alike, broadening its potential application across a wide range of pharmaceutical compounds. Additionally, the biocompatibility and biodegradability of nanomaterials play a pivotal role in ensuring their safety and clinical relevance. Despite these promising advancements, certain challenges remain, including the need for comprehensive toxicity assessments, scalability of manufacturing processes, and regulatory considerations. Nonetheless, nanotechnology-based solubility enhancement techniques hold significant promise for revolutionizing drug development and personalized medicine. In conclusion, this review underscores the transformative potential of nanotechnology-based solubility enhancement techniques in overcoming drug solubility challenges. As the field continues to evolve, further research and collaboration among academia, industry, and regulatory bodies will be essential to unlock the full therapeutic potential of nanotechnology in pharmaceutical applications.