Abstract
Nanosuspension consists of the pure poorly water-soluble drug without any matrix material suspended in dispersion. The formulation as nanosuspension is an attractive and promising alternative to solve these problems. Nanosuspension technology solved the problem of drugs which are poorly aqueous soluble and less bioavailability. Stability and bioavailability of the drugs can be improved by Nanosuspension technology. Nanosuspensions are promising candidates that can be used for enhancing the dissolution of poorly water-soluble drugs. Preparation of Nanosuspension is simple and applicable to all drugs which are aqueous insoluble. Nanosuspensions are prepared by using wet mill, high-pressure homogenizer, emulsion‐solvent evaporation, melt emulsification method and supercritical fluid techniques. Nanosuspension can be prepared by using stabilizers, organic solvents and other additives such as buffers, salts, polyols, osmogent and cryoprotectant. Nanosuspensions can be delivered by oral,parenteral, pulmonary and ocular routes. Nanosuspensions can also be used for targeted drug delivery when incorporated in the ocular inserts and mucoadhesive hydrogels.
Highlights
Uniform and accurate dose cannot be achieved unless suspension areFor an effective production of nanosuspensions using the Nanoedge technology, an evaporation step can be included to provide a solvent-free modified starting material followed by high-pressure homogenization
One of the main problems responsible for the low turnout in the development of new molecular entities drug formulations is poor solubility and poor permeability of the lead compounds
A Pharmaceutical Nanosuspension is a biphasic liquid system in which insoluble solid drug particles are uniformly dispersed in an aqueous vehicle
Summary
For an effective production of nanosuspensions using the Nanoedge technology, an evaporation step can be included to provide a solvent-free modified starting material followed by high-pressure homogenization. This technique, called opposite stream or nanotechnology, uses a chamber where a stream of suspension is divided into two or more parts, which colloid with each other at high pressure. The major disadvantage of this technique is the high number of passes through the microfluidizer and that the product obtained contains a relatively larger fraction of microparticles This technique involves preparing a solution of drug followed by its emulsification in another liquid that is a non-solvent for the drug. The disadvantages of the above methods are use of hazardous solvents and use of high proportions of surfactants and stabilizers as compared with other techniques, particle nucleation overgrowth due to transient high supersaturation, which may result in the development of an amorphous form or another undesired polymorph
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