Abstract
Evaluation of: Huang X, El-Sayed IH, Qian W, El-Sayed MA: Cancer cell imaging and photothermal therapy in the near-infrared region by using gold nanorods. J. Amer. Chem. Soc. 128(6), 2115–2120 (2006) [1] . A recent paper, one of several recent studies on the use of nanostructures in thermal cancer therapy, is evaluated here. Functionalized gold nanorods have been used in vitro to selectively destroy cancer cells by converting near infrared radiation to heat. Nanostructures with tunable optical properties and biologically relevant size show great promise in highly selective thermal ablation therapy. Gold nanorods coated with targeting antibodies were demonstrated to be selective agents for the detection and destruction of cancer cells. We present the results of the El-Sayed paper, compare gold nanorods with other near infrared-absorptive nanostructures and discuss challenges of nanostructure-mediated thermal therapy.
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