Nanostructured silver doped TiO2/CNTs hybrid as an efficient electrochemical sensor for detection of anti-inflammatory drug, cetirizine

Abstract

For developing a promising sensor, sensitivity and selectivity are the most critical key issues. In efforts to develop novel sensor materials, various types of modifiers such as carbon nanotubes, transition metals, semiconductors, and graphene have been utilized in the electrode system. In this study, a novel and highly efficient electrochemical nanosensor was fabricated using a combination of silver-doped titanium dioxide nanoparticles (Ag-TiO2) and multi-walled carbon nanotubes (MWCNTs) for the sensitive detection of cetirizine (CTZ), an anti-inflammatory drug. The complete electrochemical detection of CTZ was examined in basic pH 8.0 media by voltammetry techniques. The prepared Ag-TiO2/MWCNTs nanocomposite demonstrated an exceptional electrocatalytic performance for CTZ in contrast to the pristine electrode due to nano-Ag-TiO2and MWCNTs. Further, the electrode assembly showed CTZ electrooxidation in a linear fashion with a lower detection limit of 8.76 nM. The electrochemical oxidation of CTZ has been carried out using cyclic voltammetry (CV), Square wave voltammetry (SWV) techniques. The significance of the present technique is its sensitivity response towards CTZ detection and its assessment. The described method has been applied for the determination of CTZ in pharmaceutical formulations and urine samples. Good recovery values suggest applicability, effectiveness, and reliability of the sensor for determination of CTZ.