Abstract
Selenium-doped nanostructure has been considered as an attractive approach to enhance the antibacterial activity of calcium phosphate (CaP) materials in diverse medical applications. In this study, the selenium-doped biphasic calcium phosphate nanoparticles (SeB-NPs) were first synthesized. Then, silver was in situ incorporated into SeB-NPs to obtain nanostructured composite nanoparticles (AgSeB-NPs). Both SeB-NPs and AgSeB-NPs were characterized by Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), ultraviolet–visible spectroscopy (UV–Vis), X-ray photoelectron spectroscopy (XPS), and Raman spectra. The results confirmed that the SeO32− was doped at the PO43− position and silver nanoparticles were deposited on the surface of SeB-NPs. Next, Transmission Electron Microscopy (TEM) analysis displayed that the prepared AgSeB-NPs had a needle-cluster-like morphology. CCK-8 analysis revealed SeB-NPs and AgSeB-NPs had good cytocompatibility with osteoblasts. The antibacterial activity of the prepared AgSeB-NPs was confirmed by using Gram-negative E. coli and Gram-positive S. aureus. The above results manifested the significance of the final AgSeB-NPs for biomedical applications.
Highlights
Selenium-doped nanostructure has been considered as an attractive approach to enhance the antibacterial activity of calcium phosphate (CaP) materials in diverse medical applications
The bands for biphasic calcium phosphate (BCP) at 1,107, 1,136, and 962 cm−1 corresponded to the P–O stretching vibration modes of P O43−, while for selenium-doped biphasic calcium phosphate nanoparticles (SeB-NPs) it decreased and disappeared
FI-IR, Raman, X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS) analysis certified that the SeO32− was doped at P O43− position
Summary
Selenium-doped nanostructure has been considered as an attractive approach to enhance the antibacterial activity of calcium phosphate (CaP) materials in diverse medical applications. Silver was in situ incorporated into SeB-NPs to obtain nanostructured composite nanoparticles (AgSeB-NPs). The results confirmed that the SeO32− was doped at the PO43− position and silver nanoparticles were deposited on the surface of SeB-NPs. Transmission Electron Microscopy (TEM) analysis displayed that the prepared AgSeB-NPs had a needlecluster-like morphology. Tissue engineering has been widely used in bone graft and dentistry due to a large number of patients require grafting resulting from congenital conditions, trauma, and tumor resection, and so o n1–3 Mineralized tissues, such as bone, tooth enamel, dentin, and cementum, are enriched with significant amounts of ionic substitutions, including sodium, potassium, and carbonate groups. The synergistic effect of silver and selenium on CaP based nanoparticles in inhibiting bacteria needs to be further investigated
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