Abstract
We have successfully prepared for the first time hydroxyapatite (HAp) and calcium silicate (CaSiO3) nanostructured porous hollow ellipsoidal capsules which are constructed by nanoplate networks using the inorganic CaCO3 template. CaCO3 ellipsoids are synthesized via the reaction between Ca(CH3COO)2 and NaHCO3 in water and ethylene glycol mixed solvent at room temperature and they are used as the Ca2+ source and cores. Then a PO43− or SiO32− source is added to react with CaCO3 to form a HAp or CaSiO3 shell on the surface of CaCO3 ellipsoids. Dilute acetic acid is used to remove remaining CaCO3 cores. The size and shape of the HAp and CaSiO3 hollow capsules are determined by those of the cores. The thickness of the capsule shell can be controlled by adjusting the concentration of PO43− or SiO32− source. A number of PO43− sources such as dilute H3PO4, Na3PO4 and Na2HPO4 can be used to form HAp hollow capsules with similar morphologies. The drug loading and release behavior of HAp hollow capsules is also investigated. A typical anti-inflammatory drug, ibuprofen, is used for drug loading. The result indicates that HAp hollow capsules have a high specific surface area and high storage capacity, and favorable drug release behavior.
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