Abstract
Objective: In this study, Myrica esculenta (ME) leaves extract along with Coenzyme Q10 was entrapped in nanostructured lipid carriers (NLCs). The formulation variables were successfully optimized using 23 factorial design.Methods: Preparation of NLC was carried out by solvent injection technique. The formulation of NLC was consisting of the methanolic extract of Myrica esculenta leaves and Coenzyme Q10 as key ingredients. Oleic Acid (OA) was taken as liquid lipid, Precirol ATO 5 (PATO) as solid lipid, and Poloxamer 407 (P407). The formulation variables were statically optimized using 23 factorial design, followed by the characterization of the formulation.Results: The results demonstrated that the best optimized NLC formulation F5 of Coenzyme Q10 and plant extract exhibited the smallest size 169.46 nm and highest entrapment efficiency 90.06±0.171 %. Furthermore, it showed good physical stability at 28 d after preparation.Conclusion: The developed NLCs of Q10-ME extract from this study could be explored as the effective anti-ageing formulation.
Highlights
The human being of the modern world had a great inclination to search for an everlasting youth. In this physical world facial appearance became a crucial factor to influence social relations in many situations due to which people tend to judge personality based on facial manifestation [1]. This desire had triggered for the development of new products, methods and technology in the cosmeceutical industry which might revert back the clock [2]
Several theories have been laid down to describe the mechanism of the skin aging of which the most successful and referred is the free radical theory based on oxidative stress [4]
It is supported with the help of interaction plots obtained by the statistical design (23 factorial design)
Summary
The human being of the modern world had a great inclination to search for an everlasting youth In this physical world facial appearance became a crucial factor to influence social relations in many situations due to which people tend to judge personality based on facial manifestation [1]. This desire had triggered for the development of new products, methods and technology in the cosmeceutical industry which might revert back the clock [2]. Skin is the largest human organ contributing, a major target of oxidative stress [3]. Several theories have been laid down to describe the mechanism of the skin aging of which the most successful and referred is the free radical theory based on oxidative stress [4]
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