Nanostructured lipid carriers (NLC) system: A novel drug targeting carrier

Abstract

Lipid nanocarriers are developed as an alternative to polymeric nanoparticles, liposomes and emulsions. Further, Nanostructured Lipid Nanocarriers are the second generation lipid carriers developed to overcome problems associated with Solid Lipid Nanoparticles and are utilized in various therapeutic approaches. NLCs were primarily considered for the delivery of lipophilic drugs but their suitability for hydrophilic drugs is now well established. Biocompatible nature of lipids is responsible for its development as a promising drug delivery. It was found to be having superior characteristics over other lipid formulations. This article describes the NLC with respect to structures, methods of preparation, characterization, stability and its advantages over first generation lipid nanoparticles. Review mainly focuses on the various therapeutic applications of NLCs and their specificity for different physiological proximities. Due to their biologically non-toxic, non-immunogenic and compatible nature, NLCs are going to be the widely explored lipid nanocarrier systems.