Abstract
NAGA-loaded NLCs were formulated, using hot homogenization technique, and the characteristics of the optimized formulation were analyzed by laser light scattering, X-ray diffraction, and scanning electron microscopy methods. Loading capacity percentage and in vitro release study were carried out by applying a validated HPLC method. The optimum formulation was utilized for the in vivo skin lightening evaluations in healthy volunteers. Results: NAGA-loaded NLCs demonstrated promising results (the size of 190 nm, narrow size distribution, loading capacity of 9%, and appropriate NAGA release profile) suitable for dermal delivery. XRD results exhibited a dramatic reduction in the crystalline structure of encapsulated NAGA. Dermoscopy images indicated a considerable decline in melanin distribution pattern in the majority of the cases treated with NAGA-loaded NLCs. Conclusion: Thus, this study has opened new horizons for the potential use of lipid based nanoparticles in the managing of hyperpigmentation.
Highlights
Glucosamine is used to decrease melanogenesis in melanocyte and, has a potential to decrease hyperpigmentation by topical use
Dermoscopy images indicated a considerable decline in melanin distribution pattern in the majority of the cases treated with NAGA-loaded nanostructured lipid carriers (NLCs)
The findings of the current study revealed that the optimized NLCs were in the appropriate size range for deep skin penetration
Summary
Glucosamine is used to decrease melanogenesis in melanocyte and, has a potential to decrease hyperpigmentation by topical use. Owing to the stability restrictions of glucosamine in skincare products, the stable derivative N-acetyl glucosamine (NAGA) is utilized which is a monosaccharide derived from glucose chemically produced by linking glucosamine and acetic acid. It inhibits the tyrosinase glycosylation, a step necessary in the production of melanin. The molecules with the log p of 1-4 are suitable candidates for dermal drug delivery. It was reported that the molecules with the log p lower and higher than 1 and 4 will not properly penetrate into the stratum corneum of skin.[4]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
