Abstract
The inclusion of polyphenols into nanoporous materials may significantly improve their application as radical trapping agents for therapeutic purposes.
Highlights
Nanosponges (NSs) are materials with a nanosized porosity[13] that represent an emerging tool to improve the solubility and stability of sparingly water soluble drugs.[14,15,16] Nanosponges are hyper-cross-linked polymers or co-polymers made up of typical supramolecular host species, such as cyclodextrins (CDs) or calixarenes (CAs) as the monomers, covalently held together by means of suitable linker units
Nanosponges based on hypercross-linked cyclodextrins and calixarenes (NS1–NS3) were used as carriers of three natural phenolic antioxidants: quercetin (Que), curcumin (Cur) and phenethyl caffeate (Phec)
The goal of this work is represented by the possibility of performing a controlled release in an aqueous medium of natural antioxidants that are sparingly water soluble
Summary
Nanosponges (NSs) are materials with a nanosized porosity[13] that represent an emerging tool to improve the solubility and stability of sparingly water soluble drugs.[14,15,16] Nanosponges are hyper-cross-linked polymers or co-polymers made up of typical supramolecular host species, such as cyclodextrins (CDs) or calixarenes (CAs) as the monomers, covalently held together by means of suitable linker units. Strategy, by reacting propargyloxy-CAs with bis-azidoalkanes under the well-known CuAAC reaction conditions.[20] The same approach has been exploited to prepare mixed cyclodextrin– calixarene NS materials (CDCANSs, Fig. 1).[21,22] The latter ones present a disordered structure that is permeable to aqueous solutions and able to reversibly absorb and release diverse organic guest species (including dyes[19] and antimicrobial agents20), which
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