NanoSPECT/CT imaging and biodistribution of <sup>188</sup>Re-HSA microspheres using new radio labeling process in a GP7TB hepatoma rats model (Imaging and Biodistribution of <sup>188</sup>Re-HSA microspheres)

Abstract

The human serum albumin microsphere (HSA microsphere) is biodegradable and biocompatible, the SPECT/CT imaging and biodistribution of 188Re-HSA microspheres using new radio labeling process were investigated in a GP7TB hepatoma rat model. The labeling efficiency of the 188Re-HSA microspheres using new radio labeling process was about 97%. The levels of radioactivity within the liver peaked at 1 h (68.325777±1.896218 %ID/organ) and then declined slowly. With image analysis, the highest uptake in liver was 69.9±3.8 %ID/organ and 59.7±5.7 %ID/organ at 48 and 72 h after administration of 188Re-HSA microspheres via TACE. The liver uptake of 188Re-HSA microspheres was steadily maintained that to increase the radioactivity to directly give damage to tumor cells. These results showed potential benefit and advantage of 188Re-HSA microspheres via liver transarterial chemoembolization (TACE) for treatment of Hepatocellular carcinoma.