Abstract
TINY SPECS OF SILVER COULD play a central role in a sensitive and inexpensive biological detection system, according to a study conducted at Northwestern University. The nanoparticle- based analytical procedure might be used to monitor ligand-receptor binding events, protein adsorption on self-assembled monolayers, and other types of analyte-surface interactions. Based on a technique in which researchers measure changes in the extinction (absorption plus scattering) spectrum of microscopic metal particles, the new procedure provides a way to measure low concentrations of specific analyte molecules using simple UV-Vis spectroscopy instrumentation. Chemistry professor Richard P. Van Duyne and graduate student Amanda J. Haes demonstrated the method by detecting low picomolar quantities of biotin-strep tavidin-a model ligand-receptor system [ J. Am. Chem. Soc. , published online Aug. 8, http://dx.doi.org/10.1021/ja020393x]. The detection principle is based on a variation of surface plasmon resonance (SPR) spe...
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