Abstract
Applying nanosized ultrasound contrast agents (nUCAs) in molecular imaging has received considerable attention. nUCAs have been instrumental in ultrasound molecular imaging to enhance sensitivity, identification, and quantification. nUCAs can achieve high performance in molecular imaging, which was influenced by synthetic formulations and size. This review presents an overview of nUCAs from different synthetic formulations with a discussion on imaging and detection technology. Then we also review the progress of nUCAs in preclinical application and highlight the recent challenges of nUCAs.
Highlights
Nanosized ultrasound contrast agents, as a complementary of microbubbles, are developed as contrast enhancers for ultrasound molecular imaging with the ability of penetrating through vasculature for extravascular imaging (Krupka et al, 2010; Wang et al, 2017)
Applying nanosized ultrasound contrast agents in molecular imaging has received considerable attention. Nanosized ultrasound contrast agents (nUCAs) have been instrumental in ultrasound molecular imaging to enhance sensitivity, identification, and quantification. nUCAs can achieve high performance in molecular imaging, which was influenced by synthetic formulations and size
This review presents an overview of nUCAs from different synthetic formulations with a discussion on imaging and detection technology
Summary
Applying nanosized ultrasound contrast agents (nUCAs) in molecular imaging has received considerable attention. nUCAs have been instrumental in ultrasound molecular imaging to enhance sensitivity, identification, and quantification. nUCAs can achieve high performance in molecular imaging, which was influenced by synthetic formulations and size. Applying nanosized ultrasound contrast agents (nUCAs) in molecular imaging has received considerable attention. NUCAs have been instrumental in ultrasound molecular imaging to enhance sensitivity, identification, and quantification. NUCAs can achieve high performance in molecular imaging, which was influenced by synthetic formulations and size. This review presents an overview of nUCAs from different synthetic formulations with a discussion on imaging and detection technology. We review the progress of nUCAs in preclinical application and highlight the recent challenges of nUCAs. Reviewed by: Alessandra Quarta, Italian National Research Council, Italy Ehsan Nazarzadeh Zare, Damghan University, Iran. Specialty section: This article was submitted to Nanobiotechnology, a section of the journal Frontiers in Bioengineering and Biotechnology. Nanosized Contrast Agents in Ultrasound Molecular Imaging.
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