Nanosize effect of clay mineral nanoparticles on the drug diffusion processes in polyurethane nanocomposite hydrogels

M Miotke,J Strankowska,Ł Piszczyk,M Strankowski,M Józefowicz,J Kwela,M Gazda

doi:10.1140/epjp/i2017-11708-1

Abstract

.Studies of swelling and release of naproxen sodium (NAP) solution by polyurethane nanocomposite hydrogels containing Cloisite® 30B (organically modified montmorillonite (OMMT)) have been performed. Polyurethane nanocomposite hydrogels are hybrid, nontoxic biomaterials with unique swelling and release properties in comparison with unmodified hydrogels. These features enable to use nanocomposite hydrogels as a modern wound dressing. The presence of nanoparticles significantly improves the swelling. On the other hand, their presence hinders drug diffusion from polymer matrix and consequently causes delay of the drug release. The kinetics of swelling and release were carefully analyzed using the Korsmeyer-Peppas and the modified Hopfenberg models. The models were fitted to precise experimental data allowing accurate quantitative and qualitative analysis. We observed that 0.5% admixture of nanoparticles (Cloisite® 30B) is the best concentration for hydrogel swelling properties. The release process was studied using fluorescence excitation spectra of NAP. Furthermore, we studied swelling hysteresis; polymer chains have not been destroyed after the swelling and part of swelled solution with active substances which remained absorbed in the polymer matrix after the drying process. We have found that the amount of solution with NAP remained in the nanocomposite matrix is greater than in pure hydrogel, as a consequence of NAP-OMMT interactions (nanosize effect).

Highlights

In recent years many materials were investigated in order to find the best dressing facilitating wound healing
In the present paper we report the swelling and release properties of these new hybrid materials, i.e., a polyurethane hydrogel matrix doped with Cloisite 30B in contact with active substance, naproxen sodium (NAP)
We found that the best combination of active substances in solution in respect of swelling is 3% naproxen sodium in 50% cosolvent ethanol+water (3% NAP)

Summary

Introduction

In recent years many materials were investigated in order to find the best dressing facilitating wound healing. A good moisture between the wound and the dressing is possible by an appropriate selection of materials [2], so it is very important to understand their behaviour in the swelling and release processes. Polyurethane hydrogels are good candidates for wound dressings due to their ability to maintain environment hydrated, to absorb the solution, permeability for gases and ability of the polymer matrix to release active substances [4,5,6]. They are elastic, non-toxic, and many of them are biodegradable and bioresorbable [7]

Objectives

Methods

Results

Conclusion