Abstract
Electrochemical oxidation of mefenamic acid was investigated at the surface of carbon paste electrode with silica nanoparticles as an modifier. The electrode surface was characterized by using SEM and TEM. Voltammetric behaviour of mefenamic acid was studied using cyclic voltammetric method. A nano silica modified carbon paste electrode was used to investigate the electrochemical oxidation of mefenamic acid. Comparison of bare carbon paste electrode and silica nanoparticles modified carbon paste electrode, it was observed that the modified electrode has advantage of high sensitivity and selectivity with low detection limit. Effect of supporting electrolyte (phosphate buffer, I = 0.2 M) solution in the range, 3.0 – 11.2 pH was investigated and found that pH 5 is suitable for the investigations. In addition, effect of scan rate variations was studied to calculate some of the physiochemical properties. An electrode reaction mechanism was proposed and differential pulse voltammetric method was developed for the analytical application. Further, the applicability of the proposed method was investigated for pharmaceutical dose form and human urine samples.
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