Abstract
Nanoporous silicate materials, made by an operationally simple evaporation-induced self-assembly (EISA) approach, efficiently catalyze the formation of 2-substituted 2,3-dihydroquinazolin-4(1H)-ones from aldehydes and dimethyl acetals. This methodology can be extended to encompass the reaction of ketones and ketals to provide facile access to 2,2-disubstituted and spiro dihydroquinazolin-4(1H)-ones in high yields and short reaction times.
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