Abstract
Biological nanopores are robust platforms for the identification of a range of biomolecules, for example, nucleic acid and peptides. Although progress in DNA and RNA sequencing has seen a lot of success in recent years, progress towards applying quantitative nanopore diagnostic tools has been impeded by a few challenges. One of the major bottlenecks is the inefficient capture of molecules into a pore at low concentrations, for example, fM-level biomarker detection for cancer diagnosis. Here we present an immuno-rolling circle amplification scheme for reliable multiplexed biomarker quantification from biological fluids using a biological nanopore sensor.
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