Abstract
• Nanopeptide CMCS-20H exhibits powerful bactericidal and anti-inflammatory activities. • CMCS-20H remarkably improves survival rate and mucin thickness in intestinal villi. • CMCS-20H reduces tissue bacterial loads and intestinal inflammation and lesion. • CMCS-20H maintains intestinal microbiome homeostasis in bacterial infection. • CMCS-20H kills bacteria by membrane damage and DNA binding.
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