Nanoparticles Loaded Mucoadhesive Buccal Patches - Review

Abstract

Drug distribution for both local and systemic conditions is significantly facilitated by buccal methods of administration. When a rapid beginning of action is necessary, they have proven to be a potent substitute for the conventional oral route, the buccal route is regarded as patient-friendly. Although many procedures have been explored, drug permeability and regulated drug release via this route of delivery remain concerns for the effective therapy. They have shown to be an effective alternative to the traditional oral route, especially when fast onset of action is required. The buccal route is considered patient friendly due to its non-invasive nature and ease of administration. Nanotechnology has advanced to the point that clinical uses have been considered. The use of nanoparticles in buccal dosage forms not only provides efficient distribution but also lowers biological system side effects. Many methods for loading and delivering drug-loaded nanoparticles to the buccal mucosa have been proposed, both for topical and systemic administration. The primary objective of this review is to provide an overview of the nanotechnological methods that have been so far developed to enhance the buccal administration of medications.