Abstract
Due to an oversight of the authors, the following sentence in the caption of Figure 2 on p. 780 should be corrected. It has been changed online from: Human primary keratinocytes (normal human epidermal keratinocytes), fibroblasts (normal human dermal fibroblasts, BJ fibroblasts, CCD-1112Sk cells), and endothelial cells (human microvascular endothelial cells) have been used [11,20,88]. into: Human primary keratinocytes (normal human epidermal keratinocytes, NHEK), fibroblasts (normal human dermal fibroblasts, NHDF) have been used [20,88]. Human or mouse immortalized cells from keratinocytes (HaCaT and XB-2 cells), fibroblasts (Hs68, BJ fibroblasts, CCD-1112Sk, or NIH3T3) and human endothelial (human microvascular endothelial cells-1, HMEC-1) may also be used [11,20,89]. Immortalized cells are easy to implement but carry genotype and/or phenotype modifications leading to potentially modified cellular responses to external factors compared with primary cells, which are fragile and subject to morphological changes after subculture. Significant differences in cell migration, proliferation, response to drugs, or biocompatibility may occur according to the cells used (primary cells vs cell lines) [90]. Nanoparticle-Based Dressing: The Future of Wound Treatment?Berthet et al.Trends in BiotechnologyJune 20, 2017In BriefReconstructing functional skin after a wound remains a challenge due to the complexity of healing. In this regard, biocompatible nanoparticles (NPs) carrying and releasing bioactive drugs in a controlled and sustained manner may significantly improve the efficacy of wound therapies compared with current treatments. Topical administration of drug-loaded NPs allows optimal delivery to the dermis and improves product efficacy. Furthermore, associating NPs with scaffolds represents a new concept of ‘dressing’. Full-Text PDF
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