Abstract
Physiological optical signals in the form of transmittance and reflectance provide useful insight in the characterization of biological systems. In the present article, thermo-optical response of a lung tissue subjected to a short-pulse laser is reported. Consideration is given to a 2-D axisymmetric cylindrical lung tissue with a solid cancerous tumor. Tumor characteristics in the form of temporal transmittance and reflectance signals are analyzed. The radiative transfer equation, comprising both collimated and diffuse radiation, is solved using the discrete ordinate method. Effects of volume fraction of gold–silica nanoshells (i.e. Au/silica core–shell nanoparticles) infused in lung–tumor tissue, and also effect of respiratory lung volume on transmittance and reflectance signals are studied. Based on absorption and scattering abilities for different stages of lung volume, studies are made with a single and a train of laser pulses. Temporal transmittance signals are distinct for different stages of the respiratory lung volumes.
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