Abstract
AbstractIn order to lower the amount of amitriptyline released from PVC membrane and improve the sensitivity of the ion exchanger based PVC membrane ion selective electrode (ISE), 0.4% (m/m) clonidine‐tetraphenylborate was used as a electroactive component in PVC membrane of ISE for determination of amitriptyline with inner reference solution of 1 mM NaCl and 0.1 mM clonidine. Better reliability and selectivity compared with previous reports were acquired with a linear range of 10 nM−1.0 mM, the detect limit of 5.0 nM and average slope of 58.4 mV/decade. Fine reproducibility, stability and recoveries by the standard addition method were also acheived. The influence of the membrane thickness, inner reference solutions, supporting electrolyte, and the response time are discussed.
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