Abstract
Undesired adverse effects caused by chemodrugs cannot be neglected in antitumor therapy, and therefore, it is important to identify new medicines with desirable therapeutic efficacy and low toxicity to normal cells. A large number of natural extracts have been shown to have favorable therapeutic effects. In addition, the synergic interactions of multiple compounds are essential for antitumor activity. In this study, we propose a strategy to simultaneously deliver multiple antitumor compounds via a nanomixture and demonstrate the feasibility of this approach by delivering jujube polysaccharides (JPS) and curcumin (CUR) to CT26.WT cells. The experimental results indicate that increased uptake of nanoparticles and enhanced antitumor activity in vitro can be reached using our designed delivery system. This strategy could become a promising approach for drug delivery research.
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