Abstract
Inflammatory bowel diseases, such as Morbus Crohn or Colitis Ulcerosa, are painful for the patient and moreover difficult to treat due to the increased mucus production and the occurrence of diarrhea. [...]
Highlights
Inflammatory bowel diseases, such as Morbus Crohn or Colitis Ulcerosa, are painful for the patient and difficult to treat due to the increased mucus production and the occurrence of diarrhea
We could demonstrate that the antiinflammatory drug rolipram, when delivered by nanoparticles made of biodegradable PLGA, led to a prolonged alleviation of colitis syndromes in rats and a reduction of central nervous side effects, compared to the same dose of the drug administered as an aqueous solution [1, 2]
With respect to skin drug delivery, there is an interesting new hypothesis that nanoparticles may penetrate along hair shafts and to accumulate in hair follicles [3]
Summary
Inflammatory bowel diseases, such as Morbus Crohn or Colitis Ulcerosa, are painful for the patient and difficult to treat due to the increased mucus production and the occurrence of diarrhea. Helmholtz Institute of Pharmaceutical Research, Saarland University, Saarbrücken Germany
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