Nanomedicine and Nanoemulsion in Increasing the Availability of Antibiotics

Abstract

There is a pressing need for the discovery of new antimicrobials and novel, antimicrobial targeting strategies. Many antimicrobials in preclinical and clinical development have poor aqueous solubility, which limits their clinical development and usage due to the low bioavailability. Enhancement of bioavailability in antimicrobials is, therefore, of great importance for achieving therapeutically effective doses and desired concentrations of drugs for the treatment of infectious diseases. Nanomedicine has enormous potential for the prevention and treatment of infectious diseases. Nanoemulsion is one type of clinically useful formulation that can provide a substantial advantage over the conventional formulation of antibiotics since the antibacterial activity of antibiotics can be significantly enhanced by dispensing them in nanoparticulate dosage form. This sustained delivery system can help to deliver antibiotics with poor solubility and pharmaceutical properties, improve the systemic or local drug bioavailability and enhance the therapeutic efficacy.