Abstract

The use of nanomaterials in sensor and biosensor field is one of the hottest topics today in analytical chemistry. The advantage of using nanomaterials leads to sensors characterized by high sensitivity, stability, and an improved repeatability1. Screen-printed electrodes (SPEs) are recognized as successful sensor platforms in modern electroanalytical chemistry due to their low background, wide potential window, cost-effectiveness, and easiness of surface modification. This last property allows modifying the screen-printed electrodes (SPEs) with several nanomaterials such as carbon nanotubes, graphene, nanoparticles, graphene nanoplates (GNPs)2, etc3,4. In this work, a comparative study using these devices (SPEs) modified with different nanomaterials via drop-casting procedure is reported (Figure 1). Moreover, the modified SPEs have been morphologically and electrochemically characterized. The research activity carried out for the development of sensors and biosensors based on SPEs modified with nanomaterials will be presented. Among the different feasible applications, the use of these nano-engineered biosensors for uric acid quantification based on SPEs modified with carbon nanotubes (bare or functionalized) and graphene nanoplatelets (GNPs) will be introduced. Significant improvements in analytical parameters have been obtained, when using nano-modified SPEs with respect to biosensors based on bare SPEs. Limit of detection (LOD), linear range and Km (Michaelis-Menten Constant) undergo remarkable ameliorations (LOD going from 48 μM to 12 μM, linear range from 0.05-2 mM to 0.02-5 mM and Km from 0.43 to 1.31 mM for bare and -CO2H MWNT based biosensors, respectively). Figure1 Schematic representation of nanomaterial-modified SPE: a) by drop casting and then used to set up a biosensor, b) enzyme immobilization. Electrochemical measurements can be performed using portable instrumentation (c).

Highlights

  • Screen-printed electrodes (SPEs) are recognized as successful electroanalytical sensor platforms due to their low background current, wide potential window, cost-effectiveness, and easiness of surface modification

  • In this work, nanoengineered electrodes have been characterized by scanning electron microscopy (SEM), Raman spectroscopy, cyclic voltammetry and square wave voltammetry (SWV)

  • These platforms have been all applied in the development of an enzymatic biosensor able to monitor and quantify uric acid in the micromolar range

Read more

Summary

Introduction

Screen-printed electrodes (SPEs) are recognized as successful electroanalytical sensor platforms due to their low background current, wide potential window, cost-effectiveness, and easiness of surface modification. The main goal in the analytical field is always to develop unconventional methods and sensitive, inexpensive and user-friendly platforms.

Results
Conclusion
Full Text
Published version (Free)

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call