Abstract
Our laboratory has developed photochemical strategies for delivery of NO and CO to physiological targets that allow control of the location, timing, and dosage of such delivery. We have explored the photoreactions of the iron/sulfur/nitrosyl clusters Fe 2 (μ-SR) 2 (NO) 4 and the Cr (III) nitrito complex trans- Cr (cyclam) ( ONO ) 2 + that release NO under visible irradiation but not at longer wavelengths. Thus, we have designed new supramolecular assemblies with water-soluble semiconductor quantum dots and lanthanide near-IR upconversion materials to serve as antennae for photosensitization of reactions from analogous precursors and increase rates of NO release using longer wavelength visible light. Certain antennae have high two photon cross-sections, a feature that allows use of NIR light (where tissue transmission is maximized) to sensitize photoreactions of these systems.
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