Abstract
The aim of this study is to evaluate the use of our nano-HA/PCL composite 3D scaffolds as graft materials for mastoid cavity obliteration in an animal model. Nano-HA particles were synthesized by chemical precipitation technique and mixed them with PCL solution to make composite paste. 3D scaffolds were fabricated by a paste extruding deposition process. The nano-HA/PCL 3D scaffolds showed good in vivo bone regeneration behaviour in a rabbit model after 4 and 8 week implantation. To characterize the 3D scaffolds as a grafting material for mastoid obliteration, mastoid cavities were introduced in rats and implanted the scaffolds. After two week implantation, histological examination showed good tissue ingrowth and new bone formation behaviour. It can be argued that our nano-HA/PCL composite 3D scaffold is a promising alternative material for mastoid obliteration.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
