Abstract
Tissue-engineered scaffolds are considered a promising strategy for repairing damaged bone tissues. Further, rotary jet spinning (RJS) is an attractive technique for fabricating fibrous scaffolds. Polycaprolactone (PCL), poly l-lactic acid (PLLA), and polyurethane (PU) are bioabsorbable polyester polymers that are widely studied as bone scaffolds. Additionally, hydroxyapatite (HA) is an osteoconductive ceramic that mimics inorganic bone. In this study, RJS fibrous scaffolds were produced based on PCL, PLLA, and PU, and the influence of the addition of HA nanoparticles was evaluated. The scaffolds morphology was characterized using scanning electron microscopy (SEM), which showed a reduction in the fiber diameter for all polymers after the HA addition and a smaller diameter of fibers for PCL. Fourier-transform infrared (FTIR) spectroscopy and X-ray diffraction (XRD) confirmed the presence of HA in the composites. Moreover, thermogravimetric analysis (TGA) showed high thermal stability of HA in the composites, in which PCL-HA presented greater thermal stability than the other composites. The addition of HA increased the in vitro degradation rates of the scaffolds, in which PLLA and PU exhibited higher degradation rates than PCL. Thus, HA addition can produce bioactive fibers and modulate the thermal stability, wettability, and in vitro degradation of polymers for different bone applications.
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