Abstract
Silver nanoparticles supported on nanoscale silicate platelets (AgNP/NSP) possess interesting properties, including a large surface area and high biocide effectiveness. The nanohybrid of AgNP/NSP at a weight ratio 7/93 contains 5-nm Ag particles supported on the surface of platelets with dimensions of approximately 80×80×1 nm3. The nanohybrid expresses a trend of lower cytotoxicity at the concentration of 8.75 ppm Ag and low genotoxicity. Compared with conventional silver ions and the organically dispersed AgNPs, the nanohybrid promotes wound healing. We investigated overall wound healing by using acute burn and excision wound healing models. Tests on both infected wound models of mice were compared among the AgNP/NSP, polymer-dispersed AgNPs, the commercially available Aquacel, and silver sulfadiazine. The AgNP/NSP nanohybrid was superior for wound appearance, but had similar wound healing rates, vascular endothelial growth factor (VEGF)-A levels and transforming growth factor (TGF)-β1 expressions to Aquacel and silver sulfadiazine.
Highlights
Silver-ion compounds, such as silver sulfadiazine (SS) cream, are applied to burn wounds to promote healing because of their antibacterial and pro-healing effects. [1,2] Anti-bacterial activity is an important factor for wound healing
Montmorillonite clay comprised of primary stack units of multiple aluminosilicate sheets with average dimension of approximately 80 nm680 nm61 nm were modified into high?surface?area silicate platelets. [16,17] Individual platelets possessing high surface charges and surface area are suitable for supporting inorganic nanoparticles such as silver nanoparticles (AgNPs)
The cytotoxicity of AgNP/nanoscale silicate platelets (NSP) to human foreskin fibroblast (Hs68) cells was determined with the MTT assay [20], indicating a dose-dependent cytotoxicity
Summary
Silver-ion compounds, such as silver sulfadiazine (SS) cream, are applied to burn wounds to promote healing because of their antibacterial and pro-healing effects. [1,2] Anti-bacterial activity is an important factor for wound healing. [4] Recent developments in nanotechnology for synthesizing nanometer-size materials may provide an opportunity for enabling effective wound healing due to material surface interaction with cells and tissue. [5] In general, silver compounds are utilized as therapeutic modalities for wound management due to their biocidal activities toward a wide spectrum of microorganisms and their anti-inflammatory effects. [19] Our earlier development of the exfoliation technique for preparing nanoscale silicate platelets (NSP) [16,17,20] could provide a new material with a high surface area to interact with AgNPs. The Ag immobilized on silicate platelets (AgNP/NSP) was found to possess interesting properties, such as a high surface area and biocidal activity. The potential of AgNP/NSPs to regulate the levels of cytokines related to angiogenesis, fibrosis, and wound inflammation were evaluated
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