Abstract
Synthesis of new nanogels composed of poly N-isopropylacrylamide (PNIPAM) and poly N,N-diethylacrylamide (PNDEA) at different mole ratios of 100:0–50:50 were performed with constant acrylic acid (AA) content (NIPAM:AA mole ratio of 10:1) by free radical polymerization. The obtained nanogels were loaded with thymol and self-assembled on the surface of chitosan films to evaluate control release of the antimicrobial. The effect of temperature (8–35 °C), pH (2–8), and ions were evaluated on particle size (100–200 nm) and charge (−25--40 mv). With the increasing ratio of PNDEA in the copolymers, the lower critical solution temperature shifted gradually from 33 °C to 24 h) at 4 °C than that at 25 °C (around 6 h). All thymol loaded nanogels exhibited antimicrobial activity against E. coli and B. subtilis.
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