Nano-Formulation-Based Approaches for Chemoprevention

Abstract

Cancer, being a highly prevalent critical disorder and a substantial cause of mortality throughout the world, has an urgent need for improved therapeutics for chemoprevention. In the developing field of chemoprevention research, nanotechnology-based formulations have gained enormous importance due to their target specificity, enhanced stability, biocompatibility, and potency. Understanding the design and function of nano-formulations in the context of cancer prevention and treatment is thus of immense significance. In this chapter, we describe various types of nano-formulations being investigated in diverse cancer types. The chapter further summarizes the design of various types of nanocarriers used in different nano-formulations, followed by their targeting strategies adopted for chemoprevention. The clinical perspective of nanotherapeutics in cancer has also been highlighted along with the future prospect in this area. Nano-formulation-based chemotherapeutics are already available for use as granted FDA approval for pancreatic cancer, breast cancer, acute lymphatic leukemia, renal cancer, and lung cancer. Alongside, several nano-formulations are in various phases of clinical trials. Few cancer types, such as colorectal cancer, still have not reached the phases of the clinical trial for nano-formulations.