Abstract
Neuronal proliferation can play a crucial role as a therapeutic modality for many disorders associated with neuronal damage. The biopolymer, carboxymethyl tamarind gum (CMTG) potentiated with reduced graphene oxide (rGO) and poly vinyl alcohol (PVA) was fabricated as nanofiber films using electrospinning for possible proliferation of neuronal cells. The thin CMTG/rGO/PVA films were examined under scanning electron microscope (SEM) and found to be highly porous which facilitate the neuronal cell seeding and infiltration. Thermal analysis revealed that the addition of rGO makes the CMTG/rGO/PVA nanofibers thermally stable compared to CMTG/PVA. The PC12 cells have shown significant proliferation and viability on the CMTG/rGO/PVA nanofibers with no observed toxicity compared to CMTG/PVA and control. This infers that blending of rGO in CMTG nanofibers could effectively help in excellent neuronal proliferation by additive effect and plays a crucial role as mimicking extracellular matrix (ECM) and can be clinically evaluated for various neurodegenerative disorders.
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