Abstract
Nanofibers have emerged as a potential novel platform due to their physicochemical properties for healthcare applications. Nanofibers’ advantages rely on their high specific surface-area-to-volume and highly porous mesh. Their peculiar assembly allows cell accommodation, nutrient infiltration, gas exchange, waste excretion, high drug release rate, and stable structure. This review provided comprehensive information on the design and development of natural-based polymer nanofibers with the incorporation of herbal medicines for the treatment of common diseases and their in vivo studies. Natural and synthetic polymers have been widely used for the fabrication of nanofibers capable of mimicking extracellular matrix structure. Among them, natural polymers are preferred because of their biocompatibility, biodegradability, and similarity with extracellular matrix proteins. Herbal bioactive compounds from natural extracts have raised special interest due to their prominent beneficial properties in healthcare. Nanofiber properties allow these systems to serve as bioactive compound carriers to generate functional matrices with antimicrobial, anti-inflammatory, antioxidant, antiseptic, anti-viral, and other properties which have been studied in vitro and in vivo, mostly to prove their wound healing capacity and anti-inflammation properties.
Highlights
Nanotechnology has enabled the development of new technology to generate functional nanomaterials capable of carrying drugs in the form of dendrimers, liposomes, nanoshells, emulsions, nanotubes, and nanofibers for the treatment of certain diseases.Among them, nanofibers have offered a great potential application as a drug carrier system of synthetic or natural compounds that have poor bioavailability [1]
Since it uses centrifugal forces instead of electric fields, the Forcespinning technique consists of ejecting a polymer solution through thin needles which rotate at high-speed concation of functional and advantages cost-effective fiber membranes that, alone or in combination of provides distinguished such as higher productivity rate, around
By the e-spinning method, gelatin can be spun by using organic solvents and water, it has encountered some technical disadvantages due to the low volatility and high surface tension of water which prevents the formation of gelatin nanofibers as well as low conductivity, loss of polymeric solution viscosity, and impossibility to be spun at room temperature
Summary
Nanotechnology has enabled the development of new technology to generate functional nanomaterials capable of carrying drugs in the form of dendrimers, liposomes, nanoshells, emulsions, nanotubes, and nanofibers for the treatment of certain diseases. Nanofibers have offered a great potential application as a drug carrier system of synthetic or natural compounds that have poor bioavailability [1] They are polymeric fibers with diameters in the range of nanometers and lengths in meters. The use of isolated bioactive compounds, obtained from medicinal plants, known as synthetic medicinal plants, represents high cost and has been shown to induce negative side effects in humans. These negative effects have been attributed to the purification process that can produce toxic byproducts [4,5]. The novelty of this study is that it provides a panoramic and integrated view of the use of technology, especially nanotechnology, and ancestral medicine for the development of delivery systems with health applications that simulate different benefits through a combination unique among various active components present in each of the extracts
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