Nanofat, Microfat, Platelet Rich Plasma (PRP), Microneedling and Fractional CO2 Laser: A Regenerative Multimodality Approach and Protocol in Scar Management

Abstract

Background: Scars are the natural end-result of healing process following skin injury that extends to the reticular dermis. Recently, a worldwide effort was undertaken to investigate the regenerative potential of adipose tissue grafting, platelet rich plasma, and microneedling technique. Only few studies have shown its effect on scars. It is hypothesized that the Adipose-Derived Stem Cells (ADSCs) and numerous growth factors contained in the lipoaspirate as well as in the Platelet Rich Plasma (PRP) that contribute to the skin and scar remodeling. The purpose of this study was to evaluate the clinical regenerative effect of using combined well-arranged different collaborative modalities including: autologous microfat, nanofat graft, platelet rich plasma and microneedling followed by fractional CO2 laser on scars.