Abstract
The aim of the present study was to prepare oil-in-water nanoemulsions stabilized with a novel natural alkyl polyglucoside surfactant and to compare them with corresponding lecithin/polysorbate 80 - based nanoemulsions in terms of physicochemical properties and physical stability. Nanoemulsions were prepared by high pressure homogenization, using 20, 30 and 40% (w/w) medium chain triglyceride as oil phase, and 4, 6 and 8% (w/w) lecithin/polysorbate 80 mixture (1/1) or caprylyl/capryl glucoside as emulsifiers. The influence of emulsifier type, emulsifier concentration and oil content was investigated with respect to changes in particle size, particle size distribution, surface charge and physical stability. The influence of production parameters (number of homogenization cycles, type of homogenization process, homogenization pressure) on particle size was also investigated. Analysis was performed by photon correlation spectroscopy, laser diffraction, zeta potential, pH and electrical conductivity measurements. All formulations produced revealed a small droplet size ranging from 147 to 228 nm and a very narrow size distribution (polydispersity index range 0,072-0,124). Zeta potentials were about -20 mV and -50 mV for nanoemulsions stabilized with lecithin/polysorbate 80 and caprylyl/capryl glucoside, respectively. The results obtained during the stability studies (6 months at 25?C and 1 month at 40?C) indicated that nanoemulsion stability was influenced by their composition. Acquired results also suggested the most appropriate production parameters: 9 homogenization cycles, homogenization pressure of 500 bar and discontinuous process of homogenization.
Highlights
The results also suggested the most appropriate production parameters: 9 homogenization cycles, homogenization pressure of 500 bar and discontinuous process of homogenization
Zeta potentials were found to be about –20 and –50 mV for nanoemulsions stabilized with lecithin/polysorbate 80 and caprylyl/capryl glucoside, respectively
Summary
Nanoemulzije su nosači sa dugom i uspešnom istorijom primene u parenteralnoj ishrani, a od nedavno su počele da se intenzivno istražuju i kao nosači lekova za različite puteve primene, kao što su intravenska, oralna, rektalna, dermalna i primena u oko [1,2,3,4,5]. Uprkos decenijama istraživanja na ovom polju, još uvek nije u potpunosti razjašnjeno mogu li se ove strukture izbeći i da li njihovo prisustvo ima negativni efekat na dugoročnu stabilnost nanoemulzija [16]. Budući da upotreba APG kao potencijalnih stabilizatora nanoemulzija još uvek nije detaljno ispitana, jedan od ciljeva sprovedenog istraživanja bio je da se utvrdi da li sa emulgatorom ovog tipa mogu da se dobiju stabilne nanoemulzije sa malom veličinom kapi i uskom raspodelom veličina kapi S tim u vezi, u sprovedenom istraživanju dodatno je praćen uticaj vrste emulgatora (smeša lecitina i polisorbata 80 vs kaprilil/kapril glukozid), kao i rastućih koncentracija uljane faze (20, 30 i 40 mas.%) i emulgatora (4, 6 i 8 mas.%) na veličinu kapi, površinsko naelektrisanje i fizičku stabilnost izrađenih nanoemulzija. Drugi važan cilj istraživanja bio je da se utvrde optimalni procesni parametri za izradu nanoemulzija, variranjem postupka (kontinualan vs. diskontinualan), pritiska i broja ciklusa homogenizacije
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