Abstract
Curcumin has many interesting biological properties. However, it is poorly soluble and stable in aqueous media and its formulation is complex. Protein-stabilized nanoemulsions (NEs) are proposed as encapsulating systems to increase curcumin solubility while protecting it from degradations. Results showed that the incorporation of curcumin within the oily phase of NEs did not modify the size and the zeta potential of nanodroplets as well as NEs stability over time. A creaming phenomenon was observed in NEs over an 80-day storage period. However, droplet stabilization against coalescence was ensured by the formation of an elastic oil/water interface following the adsorption of β-lactoglobulin and/or curcumin. An in vitro study with Franz cells showed that curcumin diffused slowly through a synthetic membrane mimicking the skin. Thus, curcumin encapsulation in the dispersed phase of NEs seemed to be a promising strategy for the development of a topical formulation as NEs increased curcumin solubility and allowed its controlled diffusion through a synthetic skin model.
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