Abstract
Background: Anthocyanins, a flavonoid class of water-soluble pigments, are reported to possess several biological activities, including antioxidant, anti-inflammatory, and anti-cancer. However, anthocyanins are highly susceptible to degradation in high pH, light, heat, and oxygen during processing and storage. Conventional microencapsulation techniques fail to provide stability to anthocyanins under physiological environments mainly because of their large particle size as well as low zeta potential and encapsulation efficiency. Methods: Nanotechnology provides novel strategies for preparing nanoformulations to enhance the physicochemical stability of anthocyanins. Nanoemulsion and nanoliposome are the two most commonly used nanosystems in pharmaceutical and food-related fields. In this review, an overview of various nanoemulsion and nanoliposome systems reported recently for enhancing stability, bioavailability, and bioactivity of anthocyanins is presented. Results: Anthocyanin nanoemulsions with different oil, water, surfactant, and cosurfactant ratios were prepared from extracts of mangosteen peel, purple sweet potato, cranberry, red cabbage, blueberry, jaboticaba peel, and acai berry and evaluated for their antioxidant activity, enhancement of physicochemical stability, topical skin application, and urinary tract infection. Likewise, unilamellar and multilamellar nanoliposomes were prepared using different types and levels of lecithin without or with cholesterol from anthocyanin standards and extracts of Hibiscus sabdariffa, mulberry, elderberry, black carrot, and pistachio green hull for the evaluation of physicochemical and oxidative stability, in vitro bioaccessibility, and melanogenic activity, as well as protective effects against diabetes mellitus and cataract. Conclusion: This review provides an insight into the current nanotechnology updates on enhancement of anthocyanin stability and biological activity.
Highlights
Anthocyanins (ANCs) are a group of water-soluble pigments belonging to a flavonoid class of secondary metabolites synthesized by plants [1]
This review provides an insight into the current nanotechnology updates on enhancement of anthocyanin stability and biological activity
This review aims to overview the recent reports on nanoemulsion and nanoliposome-based preparations used for enhancing stability, bioavailability, and bioactivity of ANCs
Summary
Anthocyanins (ANCs) are a group of water-soluble pigments belonging to a flavonoid class of secondary metabolites synthesized by plants [1]. Conventional methods to enhance the stability of ANCs can be through encapsulation with various natural polymers as well as food-based proteins and polysaccharides using several classical microencapsulation techniques that are well documented [13,14,15,16,17]. These micro-delivery systems are often unstable in the physiological environment due to their large particle size as well as low zeta potential (ZP) and encapsulation efficiency (EE) [18,19,20,21,22,23]. This review aims to overview the recent reports on nanoemulsion and nanoliposome-based preparations used for enhancing stability, bioavailability, and bioactivity of ANCs
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
