Nanocrystalline aluminium oxide: a mild and efficient reusable catalyst for the one-pot synthesis of poly-substituted quinolines via Friedlander hetero-annulation

Abstract

o-Aminoaryl ketones undergo smooth condensation with α-methylene ketones in the presence of nanocrystalline aluminium oxide under mild reaction conditions to afford the corresponding poly-substituted quinolines in excellent yields. The catalyst can be recovered by simple filtration and can be recycled in subsequent reactions.