Nanocrystal for Dermatological Application: A Comprehensive Review

Abstract

Background: Dermatological problemsimposethe biggest challenges to formulation scientists because oftheinnate structure of skin that offers an excellent barrier to the topical delivery of drugs. Conventional topical delivery systems are associated with low encapsulation efficiency, stability issue and skin irritation,and reduction in therapeutic efficacy. In recent years nanocrystal has emerged as an attractive option for topical delivery due toanenhanced saturation solubility, increased surface area, adhesiveness, absence of excipients, and small particle size. Objective: The present review providesacomprehensive account of topical delivery for management of various dermatological problemsthrough nanocrystal technology. The review highlighted the aptness of drug nanocrystals for skin delivery.The various methods used for fabrication of nanocrystalsand,the mechanism of skin penetration have been included and dealt with in this review. The main emphasis has given break worth achieved in management of dermatological problem through nanocrystal so far a plethora of literature and patent filled based on nanocrystal technology for topical deliveryhave been included in this review. Conclusion: Nanocrystal based topical delivery system can bea promising approach for drugs with poor skin penetration as these system possesstremendous potential to overcome skin barrier and deliver drugs at relevant concentrations atthe local tissue level and avoid skin irritations.