Nanocomposites Based on Polymer and Hydroxyapatite for Drug Delivery Application

M Sundar Raj

doi:10.17485/ijst/2013/v6isp5.18

Abstract

This research paper tells about sustained delivery of small molecular drug ciprofloxacin using hydroxyapatite hybrid poly (vinyl alcohol) nanocomposites. Hydroxyapatite - poly (vinyl alcohol) nanocomposites are used as a vehicle to carry drug, protein, implantable materials etc. In situ synthesized hydroxyapatite hybrid poly (vinyl alcohol) matrix was characterized using different characterization techniques like XRD, SEM and FTIR. Small molecular drug ciprofloxacin was loaded into hydroxyapatite hybrid poly (vinyl alcohol) nanocomposites. The morphology of drug free and drug loaded hydroxyapatite concoction poly (vinyl alcohol) nanocomposites is observed using SEM. In-vitro drug release is quantified using UV/VIS spectrophotometer.

Highlights

Conventional form of drug delivery is not target specific and release of drug to the target site is not sustained
0.5 g of hydroxyapatite PVA nanocomposites powder is mixed with 0.10% ciprofloxacin solution to investigate the adsorption kinetics
Samples were withdrawn from the suspension and centrifuged at 2000 rpm for 10 min and the supernatant is measured at 277 nm to find the amount of drug adsorbed by the nanocomposites

Summary

Introduction

Conventional form of drug delivery is not target specific and release of drug to the target site is not sustained. Conventional drugs cause side effect and alternation in circulating the drug level. Novel drug delivery will give steady and complete drug release by polymer hybrid hydroxyapatite (HAP) that will follow a membrane diffusion controlled release mechanism [1]. In the past decade nanocomposites designing and fabrication form different biodegradable polymer and bioactive materials is an essential step to engineer bone tissue [2]. The Ca++ ions in hydroxyapatite (inorganic) hybrid with –OH group of PVA (organic) will give more mechanical strength and osteoconductivity [5, 6, 7]. Hydroxyapatite hybrid PVA nanocomposites are synthesized using biomimetic approach gives a good microporous size to carry drug with sustained and pulsatile release [18]

Methods

Results

Conclusion