Abstract
Synthosomes are a subclass of Polymersomes with a block copolymer membrane (PMOXA–PDMS–PMOXA) and a modified embedded transmembrane channel protein which acts as a selective gate. A synthosome based pH release system functioning increasing the pH from 5 to 7 was developed by introducing six histidine mutations to the OmpF constriction site (OmpF 6His). The pH-dependent compound release (acridine orange, positively charged between 5 ≤ pH ≤ 7) has been found to be tuned by the constriction site electrostatics and size by local structural modifications.
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