Abstract
Multi-polymeric nanocomposite hydrogels with multi-functional characteristics have been engineered with high interest around the globe. The ease in fine tunability with maintained compliance makes an array of nanocomposite biomaterials outstanding candidates for the biomedical sector of the modern world. In this context, the present work intends to tackle the necessity of alternatives for the treatment of diabetic foot ulcers through the formulation of nanoclay and/or polymer-based nanocomposite hydrogels. Laponite RD, a synthetic 2-D nanoclay that becomes inert when in a physiological environment, while mixed with water, becomes a clear gel with interesting shear-thinning properties. Adding Laponite RD to chitosan or gelatin allows for the modification of the mechanical properties of such materials. The setup explored in this research allows for a promising polymeric matrix that can potentially be loaded with active compounds for antibacterial support in foot ulcers, as well as enzymes for wound debridement.
Highlights
Nanotechnology, first introduced by Richard Feynman in 1959 as a new concept in science [1], was formally and experimentally introduced to the world in 1981 when IBM scientists Gerd Binnig & Heinrich Rohrer developed the first scanning tunneling microscope (STM)
Materials science is a field in which nanotechnology is being greatly explored, due to how much the bulk and surface properties previously mentioned, such as structural tunability, functionalization, and physicochemical stability, etc., are observed to change with diverse synthetization protocols in order to form customized nanostructured materials [5,6]
It was concluded that immobilized trypsin exhibited greater pH stability, which may be attributed to the conformational stabilization of the immobilized trypsin resulting from multipoint covalent cross-linking
Summary
Nanotechnology, first introduced by Richard Feynman in 1959 as a new concept in science [1], was formally and experimentally introduced to the world in 1981 when IBM scientists Gerd Binnig & Heinrich Rohrer developed the first scanning tunneling microscope (STM). Hydrogels incorporated with laponite have emerged as composite materials of high interest as promising options for applications such as tissue engineering and wound healing without the necessity of growth factors [24]. Synthetic silicate nanoplatelets, such as Laponite RD, are highly charged nanoparticles that have been demonstrated to induce blood coagulation [25]
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