Nanocarriers for targeted drug delivery

Abstract

The use of nanotechnology in targeted drug delivery systems (DDS) is the subject of extensive investigations due to limitations associated with traditional forms of drug delivery vehicles. A targeted DDS can improve the delivery and local concentration of drugs. The use of nanoparticles (NPs) and nanostructured materials for delivering drugs to the targeted zone of action is preferred owing to their optimal size and drug loading and releasing characteristics. The ability of nanodelivery systems to cross the blood brain barrier is expected to open new avenues for carrying drugs inside the brain. Moreover, nanocarriers with conjugated drugs can improve the biological distribution of medications as well as enhance their circulation in blood stream. The current review article presents the role of nanocarriers as bearer of drug delivery frameworks for achieving efficient therapeutic results. Here the focus is on the latest advancements in modifications of nanocarriers for application as targeted DDS. Controllable shapes and high surface to volume proportions make NPs as incredible candidates for drug delivery applications. Various examples discussed in this article decipher the role of nanodelivery systems as a presumptive power tool for the delivery of both single and multimodal medicines.