Abstract
The recent innovative advance in nanotechnology has led to the development of targeted drug delivery system. Targeting a molecule to a particular site with the help of a drug delivery system efficiently requires the use of specialized drug delivery systems. The invention of Nano sponges has become a significant step in overcoming the problems associated with conventional drug delivery systems. These are able to carry both hydrophilic and hydrophobic drugs. Nano sponge technology widely provide the controlled and predictable release of the drug to the targeted site. The Nano sponge particles circulate around the body and get attached with the target site and release the drug. A wide variety of drugs can be incorporated in the Nano sponge formulation since it possess a porous structure in nature. Nano sponge technology has been studied widely for the drug delivery by oral administration, topical administration and parenteral administration. Nano sponges can be used to prevent drug and protein degradation. Another important characteristic of Nano sponge is that they can improve the solubility of poorly water soluble drug. In this review advantages, composition, method of preparation, evaluation and application of different formulations of drugs and recent studies on Nano sponge have been discussed.
Highlights
Nanosponge technology is a newer and emerging technology which uses the targeted drug delivery system to release the drug in a controlled manner to the targeted site
Nano sponges made from hyper cross-linked β-cyclodextrins Nano sponges are made from materials that makes a non-porous molecules that are carriers called cyclodextrins for drug release
After the reaction is complete the product kept to cool at room temperature, add the mixture with distilled water for recovering and filtered under air oven and purification is done by soxhchlet apparatus added with ethanol for further extraction
Summary
Nanosponge technology is a newer and emerging technology which uses the targeted drug delivery system to release the drug in a controlled manner to the targeted site. They cross-link the segments of polyester to form a spherical shape which has many cavities where the drug can be stored Those narrow cavities can be filled with different type of substance .These are able to carry both hydrophilic and lipophilic drug substances and thereby increasing the solubility of poorly water soluble drug substance [1]. This technology is considered to be a novel approach which offers controlled drug delivery system for topical use. They depend only upon the loading capacities [4]
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