Abstract
ABSTRACT Nano SbCl 5 .SiO 2 as an eco-friendly and efficient nanocatalyst was applied for quinoxaline derivatives preparation with improved yield. In this protocol, α-diketones and 1,2-diamines were condensed in the presence of nanocatalyst at room temperature under solventless conditions. The method gave good yields of quinoxaline derivatives in short reaction times in comparison with earlier methods. Using nontoxic and inexpensive materials, simple work-up, short reaction times and high yields of the products are the advantages of this method. Keywords: nano SbCl 5 .SiO 2 , nano-catalyst, quinoxaline derivatives, solventless, green condensation reactions e-mail: bamoniri@kashanu.ac.ir INTRODUCTION The quinoxaline moiety is an important structural motif in the preparation of substances with pronounced biological activities 1 .The quinoxaline core is presented in many drugs with antitumor 2-3 , anticancer 4 , antiamoebic 5 , anticonvulsant 6 , antimalarial 7 , antioxidant 8 and anti- protozoal activity
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