Nano-novel approach: Self Nano Emulsifying Drug Delivery System (SNEDDS)-Review Article

Abstract

Aim: The main aim of this present thesis is to setup the novel Self Nano-emulsifying drug delivery system to enhance the better and desired bio-availability in vitro drug release and to increase their clinical efficacy when they administrated orally. Background: SNEDDS is meant for intensification of lipophilic drugs [or] poorly aqueous dissolvable drugs. NE has oil mixtures, SURFACTANT, Co-SURFACTANT, and also contains co-solvent. The mixture should be of isotropy nature. It holds micro (or) Nano-emulsion of oil containing the drug that spontaneously aqueous media on mild agitation. SNEDDS is most important application on Bio-pharmaceutics classification system [BCS class] II and IV drugs for increasing the solubility of lipophilic drug. Fats of NE improvised and increase the orally bioavailable nature of a poorly-aqueous dissolvable drugs substance, using Continuous-emulsification technique. SNEDDS is a new approach of drug-delivery-system which are significantly intravenous [parental], optic [or] preparation (optic or ocular) intra-nasal, suppository, oral (sustained release effects, pellets forms) and finally cosmetics. Result: SNEDDS significantly shows the increased the dissolution rate and prevent interfacial tension. SNEDDS under dilution in aqueous media such as gastro intestinal fluid and forms emulsion [stable].Emulsion is of oil in water [o/w] type and it has a globule sizes less than 150 Nano-meters.