Nano Green Voltammetric Determination of Imidocarb Dipropionate and Its Residues in Bovine Meat, Milk and Urine Samples

Abstract

Imidocarb dipropionate (IMD) is an antimicrobial agent that is widely used in veterinary medicine for treatment of many diseases especially anaplasma marginale in cattle. This may lead to the retention of its residues in edible bovine tissues, milk and urine samples. Thus the quick determination of minor concentrations of IMD is of great interest to ensure food safety. A novel electrochemical sensor was introduced for the sensitive, fast and selective determination of IMD in drug substance and commercial product, furthermore its application to determine IMD residues in bovine meat, milk and urine samples. The prepared nanoparticles sensor was based on a multiwalled carbon nanotube composite modified with gold nanoparticles GNPs/MWCNT. The linear response obtained for IMD using the GNP/MWCNT was found to be over the range of 0.20–3.6 n mol l−1 with a good linearity and high correlation (0.9999). The limits of detection and quantification were found to be 36 p mol l−1 and 109 p mol l−1 respectively. The developed method was simple, rapid, economic, and challenging to green chemistry. The high sensitivity, good reproducibility, and wide linear range mark the modified electrode suitable for determination of the residues in bovine meat and milk as real samples with excellent recoveries.