Abstract
A versatile and convenient way to produce bioactive poly(lactic acid) (PLA) and poly(ε-caprolactone) (PCL) electrospun nanofibrous scaffolds is described. PLA and PCL are extensively used as biocompatible scaffold materials for tissue engineering. Here, biobased nano graphene oxide dots (nGO) are incorporated in PLA or PCL electrospun scaffolds during the electrospinning process aiming to enhance the mechanical properties and endorse osteo-bioactivity. nGO was found to tightly attach to the fibers through secondary interactions. It also improved the electrospinnability and fiber quality. The prepared nanofibrous scaffolds exhibited enhanced mechanical properties, increased hydrophilicity, good cytocompatibility and osteo-bioactivity. Therefore, immense potential for bone tissue engineering applications is anticipated.
Highlights
Bone tissue engineering (BTE) is a promising approach for repairing bone defects
The obtained carbon spheres were further oxidized in nitric acid for 30 min at 90 ◦ C. nano graphene oxide dots (nGO) was obtained after rotary evaporation of the diluted acidic solution followed by freeze-drying
Transmission Electron Microscopy (TEM) and Fourier Transform Infrared Spectroscopy (FTIR) were applied to investigate the interactions between nGO and poly(lactic acid) (PLA) or PCL
Summary
Bone tissue engineering (BTE) is a promising approach for repairing bone defects. It refers to in situ implantation of a biocompatible/biodegradable scaffold which can be invaded with surrounding cells/tissue, and guide tissue regeneration towards new bone formation [1,2,3,4]. (PLA) and poly(ε-caprolactone) (PCL) are utilized as biomedical scaffold materials due to their good biocompatibility and biodegradability. Both of them are Food and Drug Administration-approved polymers and regarded as soft and hard tissue compatible bioresorbable materials [6]. PLA and PCL scaffolds have insufficient mechanical strength, limiting their application as bone scaffold in load-bearing applications. They are typically quite hydrophobic in vivo and possess no bioactivity for bio-mineral growth.
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