Abstract
In the present work, nanoparticles of previously synthesized 3a derivatives of vanillic acid were synthesized by the nanoprecipitation method. Nanoparticles were further characterized by UV–vis spectroscopy, FTIR spectroscopy, SEM analysis, XRD and zeta sizer. Diabetes was instigated in Wistar albino rats by intraperitoneal (I.P.) administration of Streptozotocin (60 mg/kg body weight). Vanillic acid (100 mg/kg), 3a (100 mg/kg) and 3aNPs (50 mg/kg) body weight were given orally for a period of 21 days. Blood glucose level and biochemical parameters such as cholesterol, triglycerides, LDL, HDL, VLDL and antioxidant parameters were assessed by using diagnostic kits. SEM analysis and PDI of 3aNPs was found to be 0.2 which indicate monodisperse distribution. Significant decline in blood glucose level (p < 0.001) was observed in antidiabetic studies along with the lipid lowering and antioxidant effect in dose-dependent manner. The noted results of the study showed that nanoparticles were found to be effective in treating diabetes.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
